Overview
Epigenomics is the study of heritable genome wide changes in phenotype (appearance) or gene expression caused by mechanisms other than changes in the underlying DNA sequence. The proper control and ordering of gene expression is associated and partially controlled through DNA sequence-independent biochemical events collectively known as epigenetic gene regulation. These include but are not limited to DNA methylation and histone modiļ¬cation through acetylation, methylation, ubiquitylation, phosphorylation, or sumoylation. Similar to the genetic information found within the sequence of DNA, epigenetic information can be inherited across generations, transmitted by mother to daughter cells, and is required for life. Epigenetic regulation is known to affect gene expression, and recent research shows that aberrant DNA methylation patterning may play a role in the manifestation, progression and therapy of several diseases. A deeper understanding of the epigenetic changes associated with disease can lead to improved diganostics and can ultimately be applied towards development of therapy.
About us
The Epigenomics Core Facility of Weill Cornell Medical College provides an array of epigenomics research resources and services to the university community and outside investigators. We offer DNA methylation profiling, protein-nucleic acid association (ChIP-Chip and ChIP-Seq) analysis, DNA sequencing, Exon Capture, RNA-seq and others. Core resources and services include sample preparation services and data generation on the Illumina HiSeq2000 platform, NimbleGen microarray system, and Sequenom MassArray.
The Epigenomics Core is now hiring a Software Engineer! Please visit our Employment Opportunities page for details.