Overview

The Epigenomics Core Facility of Weill Cornell Medicine provides an array of epigenomics and bioinformatics research resources and services that include:

  • DNA methylation profiling [More]
  • Protein-nucleic acid association [More]
  • Single Cell Transcriptomics, Immune Profiling and Epigenomics [More]
  • Spatial Transcriptomics [More]
  • Bioinformatics analysis [More]
Core resources and services include sample preparation services and data generation on the Illumina NovaSeq 6000 and MiSeq platforms.

Getting Started Request Services Pubshare FAQ Pricelist

Recent Publications

We require that core clients acknowledge the Epigenomics Core of Weill Cornell Medical College in publications and presentions enabled by our resources.

A recent paper highlighting our RRoxBS assay Transcriptomic and epigenomic analyses uncovered Lrrc15 as a contributing factor to cartilage damage in osteoarthritis:
Singh P. et al. Scientific Reports. 2021. Oct 26;11(1):21107. [PubMed]

Also, check out our paper on the comprehensive evaluation of four DNA methylation measurement platforms:
Kacmarczyk T.J. et al. Epigenetics Chromatin. 2018. May 25;11(1):21. [PubMed]
  • Pakula, H. et al. Nat Commun. 2024. Jan 8;15(1):363 [PubMed]
  • Franceschini, GM. et al. Cancer Discov. 2024. Jan 10: Epub. [PubMed]
  • Xue, D. et al. Cell Metab. 2023. Nov 7;35(11):1897-1914. [PubMed]
  • Rudqvist, NP. et al. Nat Commun. 2023. Aug 24;14(1):5146. [PubMed]
  • Ruan, J. et al. Blood 2023. May 4th; 141(18):2194-2205. [PubMed]
  • Fortin, J. et al. Proc Natl Acad Sci USA 2023. Jan 24;120(4). [PubMed]
  • Mlynarczyk, C. et al. Science 2023. Jan 20;379(6629). [PubMed]
  • Xia, Y. et al. Nat Commun. 2022. Dec 13;13(1):7704. [PubMed]
  • Suryawanshi, H. et al. PloS one 2022. Jun 3;17(6):e0267704. [PubMed]
  • Singh, N. et al. Nat Commun. 2021. Dec 21;12(1):7349. [PubMed]
  • Foox, J. et al. Genome Biol. 2021. Dec 6;22(1):332. [PubMed]
  • Chalinge, R. et al. Nat Genet. 2021. Oct;53(10):1469-1479. [PubMed]
  • Singh, P. et al. Scientific Reports. 2021. Oct 26;11(1):21107. [PubMed]
  • Doane, A. et al. Nat Immunol. 2021. Oct;22(10):1327-1340. [PubMed]
  • Emi, T. et al. Epigenetics. 2021. Oct 16; 1053-1070. [PubMed]
  • Doane, A. et al. Nat Biotechnol. 2021. Sep;39(9):1129-1140. [PubMed]
  • Shohdy, KS. et al. NPJ Genom Med. 2021. Aug 12;6(1):66. [PubMed]
  • Kotlov, N. et al. Cancer Discov. 2021. Jun;11(6):1468-1489. [PubMed]
  • Yusufova, N. et al. Nature. 2021. 589:299-305. [PubMed]

Comprehensive List of Epigenomics Core Publications via Pubmed

News

Sep 2024: We have added the new CosMx Human 6K Discovery Panel to the Single-Cell Spatial Imaging (CosMx) services. [Service Details]

Sep 2024: We are now offering Visium HD as part of our Spatial Gene Expression services. [Service Details]

May 2024: We are switching our 10X Genomics Single Cell Transcriptomics and Immune Profiling Protocols to GEM-X (version 3 for Immune Profiling and version 4 for Transcriptomics).

May 2024: Cell Multiplexing via CMOs (cellplex) for 10X Genomics Single Cell Transcriptomics are not compatible with GEM-X. If you have an ongoing project with CMOs, please discuss with the core before submitting your next service request.

Feb 2023: We are now offering 10X Genomics' Visium CytAssist Spatial Gene Expression for FFPE (H&E workflow). [Service Details]